Associate Professor (Part Time)
Department of Health Studies
The University of Chicago
5841 South Maryland Ave MC2007 Chicago, IL 60637
Director, Biomedical Informatics
NorthShore University HealthSystem
1001 University Place
Evanston, IL 60201
Our lab consists of a group of statisticians and informaticians that focus on the development of computational methods and applications in two main areas:
1. Bayesian models for complex, high-throughput, genomics and proteomics data, such as microarrays, reverse phase protein arrays, and next-generation sequencing data. Our recent activities are heavily related to the analysis of TCGA data, network models for data integration, and nonparametric Bayesian modeling for tumor heterogeneity.
2. Bayesian adaptive designs for early-phase clinical trials. We have developed a series of adaptive designs for early phase clinical trials, such as phase I dose-finding trials in oncology. Our recent activities involve the development of seamless early phase trials, subgroup discovery for biomarker trials, etc.While the two research directions are mostly parallel, we are experiencing a crossing between the two paths. There are many trials now based on biomarkers. Also, the rapid progress in genomics research has made the case for personalized medicine.