Seminar Details

Seminar Details

Title: Dissecting Genetic Architecture of Complex Diseases From Genome Wide Association Studies
Speaker: Hongyu Zhao, PhD
Speaker Link: https://publichealth.yale.edu/people/hongyu_zhao.profile
Affiliation: Yale School of Public Health
Host: Dezheng Huo, MD, PhD
Position/Department: Department Chair and Ira V. Hiscock Professor of Biostatistics, Professor of Genetics and Professor of Statistics and Data Science
Location: AMB W-229
Start: 5/16/2018 3:30:00 PM
Url: http://health.bsd.uchicago.edu/

Abstract:

Genome-wide association study (GWAS) has been a great success in the past decade, with thousands of regions in the human genome implicated for hundreds of complex diseases. However, significant challenges remain in both identifying new risk loci and interpreting results, even for samples with tens of thousands of subjects. In this presentation, we describe our recent efforts to infer the genetic architecture of complex disease through random effects models, the development of functional annotations of the human genome, and the integrated analysis of these annotations with GWAS results. The effectiveness of our methods will be demonstrated through their applications to a large number of GWASs to identify tissues/cell types that are relevant to a specific disease, to infer shared genetic contributions to several diseases, and to improve genetic disease risk predictions. This is joint work with Qiongshi Lu, Yiming Hu, Jiming Jiang, Can Yang, Ryan Powels, Qian Wang, and others.