Sang Mee Lee, PhD


  • Ph.D. (Biostatistics) 2011, University of Minnesota
  • M.S. (Statistics) 2006, Ewha Womans University, Korea
  • B.S. (Statistics) 2001, Ewah Womans University, Korea


Sang Mee Lee’s research interests are comprised of statistical genetics and applied statistics to biological and medical areas. These interests are paired with health in order to answer the health related questions with statistical evidence. Sang Mee Lee is part of the University of Chicago’s Biostatics Team and her research projects mainly include the following:
  • Gene expression data analysis: Sang Mee’s doctoral dissertation research was mainly in Gene Set Enrichment Analysis (GSEA). She suggested a novel likelihood based approach using a finite mixture model and illustrated the competitive performance of the proposed method through extensive simulation studies and application to gene expression data. She continues to develop and expand this method to evaluate more general clinical outcomes of interest.
  • Diabetes Translation Research: As the principal biostatistician of the Chicago Center for Diabetes Translation Research, Sang Mee works to improve diabetes care and outcomes for vulnerable populations with diabetes. One of this group’s main goals is to help reduce racial and ethnic disparities in care.
  • Cancer Studies: One of the main projects that Sang Mee is a part of, is about hematologic malignancies with identification of high-risk human leucocyte antigen (HLA) in unrelated donor hematopoietic cell transplantation. The group evaluated about 400 amino acid substitution positions and types using a combination of Random Forest and logistic regression. This demonstrated a potential shift in the approach currently used for selection of mismatched donors to a more defined structural approach.


  • Mark A. Applebaum, Tara O. Henderson, Sang Mee Lee, Navin Pinto, Samuel L. Volchenboum and Susan L. Cohn. “Second Malignancies in Patients with Neuroblastoma: The Effects of Risk-Based Therapy." (2015) Pediatric Blood & Cancer, 62(1), 128-33
  • Shantanu Nundy, Anjuli Mishra, Patrick Hogan, Sang Mee Lee, Marla C. Solomon, Monica E. Peek. "How do mobile phone diabetes programs drive behavior change? Evidence from a mixed methods observational cohort study." (2014) The Diabetes Educator, 40(6), 806-19
  • Mark K Ferguson, MD, Katherine Thompson, Megan Huisingh-Scheetz, Jeanne Farnan, Josh A Hemmerich, Kris Slawinski, Julissa Acevedo, Sang Mee Lee, Marko Rojnica, Stephen Small. "Thoracic Surgeons' Perception of Frail Behavior in Videos of Standardized Patients" (2014) PLOS ONE, 9(6)
  • Arshiya A. Baig, Cara A. Locklin, Amanda Campbell, Cynthia T. Schaefer, Loretta J. Heuer, Sang Mee Lee, Marla C.Solomon, Michael T.Quinn, J.Martin Vargas, Deborah L.Burnet, Marshall H.Chin. "Community Health Center Provider and Staff's Spanish Language Ability and Cultural Awareness." (2014) The Journal of Health Care for the Poor and Underserved, 25(2), 527-545
  • Neda Laiteerapong, James Kirby, Yue Gao, Tzy-Chyi Yu, Ravi Sharma, Robert Nocon, Sang Mee Lee, Marshall H. Chin, Aviva Nathan, Quyen Ngo-Metzger, Elbert S. Huang. "Comparison of Health Care Utilization and Receipt of Preventive Care Between Federally Funded Health Centers and Other Sites of Outpatient Care." (2014) Health Services Research, 49(5), 1498-1518
  • Sang Mee Lee, Theodore Karrison, Nancy J Cox and Hae Kyung Im. “Quantitative Allelic Test – a Fast Test for Very Large Association Studies.” (2013) Genetic Epidemiology
  • Maneesh Bhargava, Sanjoy Dey, Trisha Becker, Michael S Steinbach, Baolin Wu, Sang Mee Lee, LeeAnn Higgins, Vipin Kumar, Peter Bitterman, David Ingbar and Christine Wendt.“Protein Expression Profile of Rat Type Two Alveolar Ep- ithelial Cells During Hyperoxic Stress and Recovery.” (2013) American Journal of Physiology-Lung Cellular and Molecular Physiology.
  • Arshiya A.Baig, Cara A.Locklin, Amanda Campbell, Cynthia T.Schaefer, Loretta J.Heuer, Sang Mee Lee, Marla C.Solomon, Michael T.Quinn, J.Martin Var- gas, Deborah L.Burnet, Marshall H.Chin. “Community Health Center Access to Resources for their Patients with Diabetes.” (2013) Journal of Immigrant and Minority Health.
  • Sang Mee Lee, Baolin Wu, and John H. Kersey. “Likelihood based approach to gene set enrichment analysis with a finite mixture model.” (2012) Statistics in Biosciences, 1-17.
  • Robert S. Nocon, Ravi Sharma, Jonathan M. Birnberg, Quyen Ngo-Metzger, Sang Mee Lee and Marshall H. Chin. “Association Between Patient-Centered Medical Home Rating and Operating Cost at Federally Funded Health Centers.” (2012) The Journal of the American Medical Association, 308(1), 60-66.
  • Seung-Ho Kang, Sang Mee Lee and Chul W.Ahn. “An Investigation of the Proportion Designs based on a Molecularly Targeted Endpoint.” (2008) Drug In- formation Journal, 42, 527-535.