Churpek, Matthew


Dr. Churpek is a Pulmonary and Critical Care physician with a PhD in Epidemiology whose research interests include developing clinical prediction models for patients who experience clinical deterioration in the hospital. His research aims to decrease preventable hospital death by identifying patients on the hospital wards who are at high risk of cardiac arrest or intensive care unit transfer early enough to improve their outcomes. Dr. Churpek is interested in the use of techniques such as survival analysis, machine learning, and simulation studies to improve the care of hospitalized patients, and he is supported by a K08 grant (K08HL121080) and R01 grant (R01GM123193).

  • Ph.D. (Epidemiology) 2013, University of Chicago
  1. Lyons PG, Snyder A, Sokol S, Edelson DP, Mokhlesi B, Churpek MM. Association Between Opioid and Benzodiazepine Use and Clinical Deterioration in Ward Patients. J Hosp Med. 2017 Jun; 12(6):428-434. PMID: 28574532.

  2. Parker WF, Garrity ER, Fedson S, Churpek MM. Potential impact of a shock requirement on adult heart allocation. J Heart Lung Transplant. 2017 May 17. PMID: 28579114.

  3. Edelson DP, Churpek MM. Annals for Hospitalists Inpatient Notes - Predicting Codes-A Future With Fewer In-Hospital Cardiac Arrests. Ann Intern Med. 2017 May 16; 166(10):HO2-HO3. PMID: 28505657.

  4. Churpek MM, Snyder A, Han X, Sokol S, Pettit N, Howell MD, Edelson DP. Quick Sepsis-related Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and Early Warning Scores for Detecting Clinical Deterioration in Infected Patients outside the Intensive Care Unit. Am J Respir Crit Care Med. 2017 Apr 01; 195(7):906-911. PMID: 27649072.

  5. Volchenboum SL, Mayampurath A, Göksu-Gürsoy G, Edelson DP, Howell MD, Churpek MM. Association Between In-Hospital Critical Illness Events and Outcomes in Patients on the Same Ward. JAMA. 2016 12 27; 316(24):2674-2675. PMID: 28027358.

  6. Churpek MM, Edelson DP. Moving Beyond Single-Parameter Early Warning Scores for Rapid Response System Activation. Crit Care Med. 2016 Dec; 44(12):2283-2285. PMID: 27858814.

  7. Adegunsoye A, Hrusch CL, Bonham CA, Jaffery MR, Blaine KM, Sullivan M, Churpek MM, Strek ME, Noth I, Sperling AI. Skewed Lung CCR4 to CCR6 CD4+ T Cell Ratio in Idiopathic Pulmonary Fibrosis Is Associated with Pulmonary Function. Front Immunol. 2016; 7:516. PMID: 27933058.

  8. Perman SM, Stanton E, Soar J, Berg RA, Donnino MW, Mikkelsen ME, Edelson DP, Churpek MM, Yang L, Merchant RM. Location of In-Hospital Cardiac Arrest in the United States-Variability in Event Rate and Outcomes. J Am Heart Assoc. 2016 Sep 29; 5(10). PMID: 27688235.

  9. Kipnis P, Turk BJ, Wulf DA, LaGuardia JC, Liu V, Churpek MM, Romero-Brufau S, Escobar GJ. Development and validation of an electronic medical record-based alert score for detection of inpatient deterioration outside the ICU. J Biomed Inform. 2016 Dec; 64:10-19. PMID: 27658885.

  10. Koyner JL, Adhikari R, Edelson DP, Churpek MM. Development of a Multicenter Ward-Based AKI Prediction Model. Clin J Am Soc Nephrol. 2016 Nov 07; 11(11):1935-1943. PMID: 27633727.

  11. Greenberg JA, David MZ, Churpek MM, Pitrak DL, Hall JB, Kress JP. Sequential Organ Failure Assessment Score Modified for Recent Infection in Patients With Hematologic Malignant Tumors and Severe Sepsis. Am J Crit Care. 2016 Sep; 25(5):409-17. PMID: 27587420.

  12. Kang MA, Churpek MM, Zadravecz FJ, Adhikari R, Twu NM, Edelson DP. Real-Time Risk Prediction on the Wards: A Feasibility Study. Crit Care Med. 2016 Aug; 44(8):1468-73. PMID: 27075140.

  13. Bhattacharjee P, Edelson DP, Churpek MM. Identifying Patients With Sepsis on the Hospital Wards. Chest. 2017 Apr; 151(4):898-907. PMID: 27374948.

  14. Churpek MM, Wendlandt B, Zadravecz FJ, Adhikari R, Winslow C, Edelson DP. Association between intensive care unit transfer delay and hospital mortality: A multicenter investigation. J Hosp Med. 2016 Nov; 11(11):757-762. PMID: 27352032.

  15. Hamilton DE, Press VG, Twu NM, Yuen TC, Azu CN, Churpek MM, Edelson DP. Testing the functional assessment of mentation: A mobile application based assessment of mental status. J Hosp Med. 2016 Jul; 11(7):463-6. PMID: 26882263.

  16. Churpek MM, Adhikari R, Edelson DP. The value of vital sign trends for detecting clinical deterioration on the wards. Resuscitation. 2016 May; 102:1-5. PMID: 26898412.

  17. Churpek MM, Yuen TC, Winslow C, Meltzer DO, Kattan MW, Edelson DP. Multicenter Comparison of Machine Learning Methods and Conventional Regression for Predicting Clinical Deterioration on the Wards. Crit Care Med. 2016 Feb; 44(2):368-74. PMID: 26771782.

  18. Churpek JE, Marquez R, Neistadt B, Claussen K, Lee MK, Churpek MM, Huo D, Weiner H, Bannerjee M, Godley LA, Le Beau MM, Pritchard CC, Walsh T, King MC, Olopade OI, Larson RA. Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemia. Cancer. 2016 Jan 15; 122(2):304-11. PMID: 26641009.

  19. Lyons PG, Zadravecz FJ, Edelson DP, Mokhlesi B, Churpek MM. In response to "Obstructive sleep apnea and adverse outcomes in surgical and nonsurgical patients on the wards". J Hosp Med. 2016 Feb; 11(2):157. PMID: 26606686.

  20. Churpek MM, Zadravecz FJ, Winslow C, Howell MD, Edelson DP. Incidence and Prognostic Value of the Systemic Inflammatory Response Syndrome and Organ Dysfunctions in Ward Patients. Am J Respir Crit Care Med. 2015 Oct 15; 192(8):958-64. PMID: 26158402.

  21. Shah T, Churpek MM, Coca Perraillon M, Konetzka RT. Response. Chest. 2015 Oct; 148(4):e134-e135. PMID: 26437829.

  22. Zadravecz FJ, Tien L, Robertson-Dick BJ, Yuen TC, Twu NM, Churpek MM, Edelson DP. Comparison of mental-status scales for predicting mortality on the general wards. J Hosp Med. 2015 Oct; 10(10):658-63. PMID: 26374471.

  23. Lyons PG, Zadravecz FJ, Edelson DP, Mokhlesi B, Churpek MM. Obstructive sleep apnea and adverse outcomes in surgical and nonsurgical patients on the wards. J Hosp Med. 2015 Sep; 10(9):592-8. PMID: 26073058.

  24. Shah T, Churpek MM, Coca Perraillon M, Konetzka RT. Understanding why patients with COPD get readmitted: a large national study to delineate the Medicare population for the readmissions penalty expansion. Chest. 2015 May; 147(5):1219-1226. PMID: 25539483.

  25. Churpek MM, Yuen TC, Winslow C, Hall J, Edelson DP. Differences in vital signs between elderly and nonelderly patients prior to ward cardiac arrest. Crit Care Med. 2015 Apr; 43(4):816-22. PMID: 25559439.

  26. Churpek MM, Edelson DP. In search of the optimal rapid response system bundle. J Hosp Med. 2015 Jun; 10(6):411. PMID: 25772513.

  27. Patel AR, Zadravecz FJ, Young RS, Williams MV, Churpek MM, Edelson DP. The value of clinical judgment in the detection of clinical deterioration. JAMA Intern Med. 2015 Mar; 175(3):456-8. PMID: 25558851.

  28. Razi RR, Churpek MM, Yuen TC, Peek ME, Fisher T, Edelson DP. Racial disparities in outcomes following PEA and asystole in-hospital cardiac arrests. Resuscitation. 2015 Feb; 87:69-74. PMID: 25497394.

  29. Churpek JE, Walsh T, Zheng Y, Moton Z, Thornton AM, Lee MK, Casadei S, Watts A, Neistadt B, Churpek MM, Huo D, Zvosec C, Liu F, Niu Q, Marquez R, Zhang J, Fackenthal J, King MC, Olopade OI. Inherited predisposition to breast cancer among African American women. Breast Cancer Res Treat. 2015 Jan; 149(1):31-9. PMID: 25428789.

  30. Churpek MM, Yuen TC, Winslow C, Robicsek AA, Meltzer DO, Gibbons RD, Edelson DP. Multicenter development and validation of a risk stratification tool for ward patients. Am J Respir Crit Care Med. 2014 Sep 15; 190(6):649-55. PMID: 25089847.

  31. Town JA, Churpek MM, Yuen TC, Huber MT, Kress JP, Edelson DP. Relationship between ICU bed availability, ICU readmission, and cardiac arrest in the general wards. Crit Care Med. 2014 Sep; 42(9):2037-41. PMID: 24776607.

  32. Churpek MM, Yuen TC, Park SY, Gibbons R, Edelson DP. Using electronic health record data to develop and validate a prediction model for adverse outcomes in the wards*. Crit Care Med. 2014 Apr; 42(4):841-8. PMID: 24247472.

  33. Yoder JC, Yuen TC, Churpek MM, Arora VM, Edelson DP. A prospective study of nighttime vital sign monitoring frequency and risk of clinical deterioration. JAMA Intern Med. 2013 Sep 09; 173(16):1554-5. PMID: 23817602.

  34. Churpek MM, Yuen TC, Edelson DP. Predicting clinical deterioration in the hospital: the impact of outcome selection. Resuscitation. 2013 May; 84(5):564-8. PMID: 23022075.

  35. Edelson DP, Churpek MM. Sifting through the heterogeneity of the Rapid Response System literature. Resuscitation. 2012 Dec; 83(12):1419-20. PMID: 23000360.

  36. Churpek MM, Yuen TC, Park SY, Meltzer DO, Hall JB, Edelson DP. Derivation of a cardiac arrest prediction model using ward vital signs*. Crit Care Med. 2012 Jul; 40(7):2102-8. PMID: 22584764.

  37. Churpek MM, Hall JB. Measuring and rewarding quality in the ICU: the yardstick is not as straight as we wish. Am J Respir Crit Care Med. 2012 Jan 01; 185(1):3-4. PMID: 22210782.

  38. Churpek MM, Yuen TC, Huber MT, Park SY, Hall JB, Edelson DP. Predicting cardiac arrest on the wards: a nested case-control study. Chest. 2012 May; 141(5):1170-1176. PMID: 22052772.

  39. El-Meanawy MA, Schelling JR, Pozuelo F, Churpek MM, Ficker EK, Iyengar S, Sedor JR. Use of serial analysis of gene expression to generate kidney expression libraries. Am J Physiol Renal Physiol. 2000 Aug; 279(2):F383-92. PMID: 10919859.

Dr. Churpek may serve as an advisor in the PhD and MS programs. His website may be found here.