EDUCATION

• Ph.D. (Statistics)1985, University of Chicago
• M.S. (Statistics) 1975, University of Chicago
• B.A. (Mathematics & Computer Science) 1974, University of Illinois

RESEARCH INTERESTS

• Clinical trials and clinical trials methodology
• Survival analysis
• Treatment and outcomes of breast cancer

SELECTED PUBLICATIONS

• Karrison T. Restricted mean life with adjustment for covariates. Journal of the American Statistical Association, 82(400):1169-1176 (1987).
• Meier P, Ferguson DJ, and Karrison T. A controlled trial of extended radical vs. radical mastectomy: ten-year results. Cancer, 63:188-195 (1989).
• Karrison T. Comparison of median survival times with adjustment for covariates. Statistics in Medicine, 14(23):2537-2553 (1995).
• Karrison T. Confidence intervals for median survival times under a piecewise exponential model with proportional hazards covariate effects. Statistics in Medicine, 15(2):171-182 (1996).
• Karrison T and Ober C. Recurrent miscarriage (REMIS) study: how should data from women who do not become pregnant be handled? Controlled Clinical Trials, 19:430-439 (1998).
• Karrison TG, Ferguson DJ, and Meier P. Dormancy of mammary carcinoma after mastectomy. Journal of the National Cancer Institute, 90 (1999).
• Ober, C.O., Karrison, T., Odem, R.R., Barnes, R.B., Branch, D. W., Stephenson, M.D., Baron, B, Walker, M.A., Scott, J.R., and Schreiber, J.R. The Recurrent Miscarriage (REMIS) Study: Mononuclear cell immunisation in prevention of recurrent miscarriages: a randomised trial, Lancet 354:365-369 (1999).
• Karrison TG, Huo D, and Chappell R. A group sequential, response-adaptive design for randomized clinical trials, Controlled Clinical Trials 24:506-522 (2003).
• Karrison TG and O'Brien PC. A rank-sum-type test for paired data with multiple endpoints, Journal of Applied Statistics 31:229-238 (2004).
• Innocenti F, Undevia SD, Iyer L, Chen PX, Das S, Kocherginsky M, Karrison T, Janisch L, Ramirez J, Rudin CM, Vokes EE, and Ratain MJ. Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan, J Clin Oncology 22:1382-1388 (2004).
• Yuan C-S, Wei G, Dey L, Karrison T, Nahlik L, Maleckar S, Kasza K, Ang-Lee M, and Moss J. American ginseng reduces warfarin's effect in healthy subjects: A randomized controlled trial, Annals of Internal Medicine 141:23-27 (2004).
• Meier P, Karrison T, Chappell R, Xie H. The price of Kaplan-Meier, Journal American Statistical Assn 99: 890-896 (2004).

MAJOR COURSES

• Statistical Methods in Clinical Research

OTHER ACTIVITIES

• Member, VA Cooperative Studies Scientific Merit Review Board, 2005-present
• Board of Directors, Society for Clinical Trials, 1998-2002
• President, Association of GCRC Statistician, 1998-1999
• Chairman, Society for Clinical Trials Student Scholarship Committee, 1992-1995
• Associate Editor, Controlled Clinical Trials, 1999-present
• Program Chair, Society for Clinical Trials annual meeting, 2004
• Member, Data Monitoring Committee:

VA CSP #379 Aneurysm Detection and Management Trial (ADAM), 1992-1999
NIH-sponsored African-American Study of Kidney Disease and Hypertension (AASK), 1996-2001
NIH-sponsored Decompression Intervention of Variceal Rebleeding Trial (DIVERT), 1998-2004
VA CSP #465 Glycemic Control and Complications in Diabetes Mellitus Type II (VADT) 2002-present
VA CSP #498 Open vs. Endovascular Repair of Abdominal Aortic Aneurysms (OVER), 2002-present

OTHER COLLEAGUES

• Carole Ober
• Paul Meier