Dignam-James | Department of Health Studies

EDUCATION

Ph.D. (biostatistics), 1994 University of Pittsburgh
M.S. (biostatistics), 1990 University of Pittsburgh
B.A., (mathematics), 1986 Saint Xavier College

RESEARCH INTERESTS

Cancer clinical trial design and interim monitoring
Racial/ethnic background and cancer prognosis
Competing risks and multiple endpoints in survival analysis

SELECTED PUBLICATIONS

Dignam JJ, Kocherginsky M. Choice and interpretation of statistical tests used when competing risks are present. Journal of Clinical Oncology, in press, 2008
Bouman P, Meng XL, Dignam J, Dukic V. A multiresolution hazard model for multicenter survival studies: Application to tamoxifen treatment in early stage breast cancer. Journal of the American Statistical Association, 102:1145-1157, 2007
Dukic V, Dignam J. Bayesian hierarchical multiresolution model for the study of time-dependent patterns of failure in early stage breast cancer. Bayesian Analysis 2:591-610, 2007
Dignam JJ, Wieand K, Rathouz PJ. A missing data approach to semi-competing risks problems. Statistics in Medicine 26:837-856, 2007
Dignam JJ, Polite B, Yothers G, Raich P, Colangelo L, O’Connell M, Wolmark N. Body mass index and outcomes in patients who receive adjuvant chemotherapy for colon cancer. Journal of the National Cancer Institute 98:1647-1654, 2006
Dignam JJ, Wieand K, Johnson K, Raich P, Anderson SJ, Somkin C, Wickerham DL. Effects of obesity and race on prognosis in lymph node-negative, estrogen receptor negative breast cancer. Breast Cancer Research and Treatment 97:245-254, 2006
Dignam JJ. Early Viewing of Noninferiority Trials in Progress (editorial). Journal of Clinical Oncology 23:5461-5463, 2005
Habel LA, Dignam JJ, Land SR, Salane M, Capra AM, Julian T. Mammographic Density and Risk of Invasive Cancer after DCIS. Journal of the National Cancer Institute, 96:1467-72, 2004.
Fisher B, Jeong JH, Bryant J, Anderson S, Dignam J, Fisher ER, Wolmark N. Treatment of Lymph Node-Negative, Estrogen Receptor-Positive Breast Cancer: Long-Term Findings from National Surgical Adjuvant Breast and Bowel Project Randomized Clinical Trials. The Lancet, 364:858-868, 2004.
Dignam JJ, Mamounas EP. Obesity and Breast Cancer Prognosis: An Expanding Body of Evidence (editorial). Annals of Oncology, 15:850-851, 2004.
Grushko TA, Dignam JJ, Das S, Blackwood AM, et al. MYC is Amplified in BRCA1-Associated Breast Cancers. Clinical Cancer Research, 10:499-507, 2004.
Dignam JJ. The Role of Cancer Cooperative Groups Within the Spectrum of Cancer Care. Cancer Control, 11:55-63, 2004.
Bryant J, Dignam JJ. Semiparametric Models for Cumulative Incidence Functions. Biometrics, 60:182-190, 2004.
Dignam JJ, Wieand K, Johnson KA, Fisher B, Xu L, Mamounas EP. Obesity, Tamoxifen Use, and Outcomes in Women with Estrogen Receptor Positive Early Breast Cancer. Journal of The National Cancer Institute, 95:1467-1476, 2003.
Dignam JJ, Ye Y, Colangelo L, Smith R, et al. Prognosis After Rectal Cancer in Blacks and Whites Participating in Adjuvant Therapy Randomized Trials. Journal of Clinical Oncology,21:413-20, 2003.
Dignam JJ, Bryant J, Paik S. Statistical Considerations in Assessing Molecular Markers of Cancer Prognosis and Treatment Efficacy. In Biostatistical Methods, edited by S.W. Looney. Methods in Molecular Biology Series vol. 184. Humana Press, Totowa, NJ, 2002, pp. 169-189.
Dignam JJ. Efficacy of Systematic Adjuvant Therapy for Breast Cancer in African-American and Caucasian Women. Journal of the National Cancer Institute Monographs, 30:36--43, 2001.
Dignam JJ, Bryant J, Wieand HS. "Early Stopping of Cancer Clinical Trials." In: Handbook of Statistics in Clinical Oncology, edited by J. Crowley. Marcel Dekker Publishers, New York, 2001, pp. 189-209.
Dignam JJ, Colangelo L, Tian W, Jones J, et al. Outcomes among African-Americans and Caucasians in Colon Cancer Adjuvant Therapy Trials: Findings From the National Surgical Adjuvant Breast and Bowel Project. Journal of the National Cancer Institute,91:1933-40, 1999.
Fisher B, Dignam J, Wolmark N, Wickerham DL, et al. Tamoxifen in Treatment of Intraductal Breast Cancer: National Surgical Adjuvant Breast and Bowel Project B-24 Randomised Controlled Trial. The Lancet,353:1993-2000, 1999.
Dignam JJ, Weissfeld LA, Anderson SJ. Methods for Bounding the Marginal Survival Distribution. Statistics in Medicine,14:1985-1998, 1995.

MAJOR COURSES

HSTD 32100 - Introduction to Biostatistics - Syllabus & Datasets
HSTD 32900 - Design and Analysis of Clinical Trials
HSTD 33100 - Introduction to Survival Analysis

LAST UPDATED April 14, 2008

Last Updated: August 24, 2009