EDUCATION

• PhD (Biostatistics), 2008, University of Washington - Seattle
• BS (Economics), 2002, Peking University - Beijing, China

RESEARCH INTERESTS

Lin Chen's research interests focus on developing statistical methods for high-dimensional genomics data and exploring the theory behind them. Always motivated by real data problems, Dr. Chen collaborates with epidemiologists, geneticists and other scientists and wishes to contribute to the statistical methodology development that facilitates the understanding of both complex disease etiology and molecular biology. Specifically, she is interested in:

• Set-based methods for association in the next generation sequencing studies
• Population stratification for rare variants from sequencing studies
• Regularized methods for extimation and testing in high-dimensional data, especially when sample seze is limited
• Missing data with non-random missing patterns in proteomics data

SELECTED PUBLICATIONS

• Chen LS, Debashis Paul, Prentice RL and Wang P. (2011) A regularized Hotelling’s T2 test for pathway analysis in proteomics studies. Accepted by Journal of the American Statistical Association.
• Prentice RL, Paczesny S, Aragaki A, Amon L, Chen LS, Pitteri S, McIntosh M, Wang P, Hsia J, Jackson R, Rossouw JE, Manson JE, Johnson K, Eaton C, Hanash SM. (2010) Plasma protein concentrations and the risk of coronary heart disease and stroke among postmenopausal women. Genome Medicine. 2:48.
• Chen LS, Hutter CM, Potter JD, Liu Y, Prentice RL, Peters U and Hsu L. (2010) Insights into colon cancer etiology using a regularized approach to gene set analysis of GWAS data. American Journal of Human Genetics. 86 (6): 860-871.
• Pitteri SJ, Hanash SM, Agragaki A, Amon L, Chen LS, Buson TB, Paczesny S, Katayama H, Wang H, Johnson MM, Zhang Q, McIntosh M, Wang P, Kooperberg C, Rossouw JE, Jackson R, Manson JE, Hsia J, Liu S, Martin L and Prentice RL. (2009) Postmenopausal estrogen and progestin effects on the serum proteome. Genome Medicine, 1(12): 121.
• Chen LS and Storey JD. (2008) Eigen-R2 for dissecting the variation of high-dimensional studies, Bioinformatics, 24 (19): 2260-2262.
• Chen LS, Emmert-Streib F, and Storey JD. (2007) Harnessing naturally randomized transcription to infer regulatory relationships among genes. Genome Biology, 8: R219.
• Dembo G, Chen L, Vater Y, Breslow N and Martay K. (2006) Double blind randomized controlled trial on the effects of mannitol on the postreperfusion syndrome during orthotopic liver transplantations. International Journal of Anaesthesia, 6: 1-13.
• Chen L and Storey JD. (2006) Relaxed significance criteria for linkage analysis. Genetics, 173: 2371-2381.

Last Updated: September 30, 2011